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FAQs

Browse our frequently asked technical questions by selecting a product below.

What is AptaLock™ technology?

AptaLock™ is an innovative proprietary technology that uses an aptamer-like molecule to confer hot start activity to the polymerase. It is an alternative method to antibody-mediated hot start.  The AptaLock™ molecule reversibly binds and inhibits the 3′-5′ exonuclease and 5′-3′ polymerase activities of the enzyme at temperatures below 40°C. This allows the reaction to be set up at room temperature without the loss of sensitivity and specificity as a result of primer dimer formation and non-specific amplification.

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